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KMID : 0370220160600010046
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Yakhak Hoeji
2016 Volume.60 No. 1 p.46 ~ p.50
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Injectable Sustained Release Gel as a Local Drug Delivery for Periodontal Diseases
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김기준:Kim Ki-Jun
신영희:Shin Young-Hee
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Abstract
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The purpose of this study was the development of sustained-release lyogel of chlorhexidine in the treatment of periodontal diseases. A sustained-release chlorhexidine lyogel (CHX-G) was formulated, based on Eudragit® (1~3%), polyvinyl pyrrolidone (PVP) (0~10%), triacetin (20~40%), hydroxy ethyl cellulose (HEC) (1%) and glycerin. In vitro studies were performed to determine the release rate of chlorhexidine from CHX-Gs using dialysis tube. Our results suggest that
the release rate of chlorhexidine from lyogel could be controlled by changing the lyogel compositions.
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KEYWORD
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chlorhexidine, sustained-release, lyogel, periodontal diseases
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